Blood Grouping Reagents

Torax Biosciences offers a comprehensive range of Blood Grouping reagents.

Monoclonal ready to use blood grouping reagents for slide and tube methods are available in bulk or filled formats. Also blood grouping range includes ABO grouping reagents, Anti D, AHG, Bovine Serum Albumin and special blood grouping reagents comprising of lectins, MNS System, Kell system and the Lewis system.

Torax uses mouse monoclonal antibodies from European sources to manufacture these reagents. Products are known to show batch to batch consistency, high potency, high specificity and titres.

What are blood group reagents?

Blood group reagents are solutions that can be used to determine ABO, Rhesus, Kell and MNS blood groups These classifications of human blood are all based on the presence or absence of certain antigens on the surface of red blood cells. The reagents can cause the agglutination (clumping) on the test red blood cells which carry a certain antigen. No clumping of the test red blood cells can indicate the absence of a certain antigen.

Determining blood types

There are 4 ABO blood group types, which are O, A, B and AB. The ABO blood group is determined by the presence or absence of certain antigens on the surface of red blood cells and by the presence or absence of certain antibodies in the blood plasma. The rhesus (Rh) reagents are used to detect the presence of the D antigen on the surface of red blood cells in humans. Anti-A, Anti-B and Anti-A,B reagents are used to determine the ABO blood group, while the different Anti-D reagents are used to determine the rhesus D type.

Identifying antigens

Other reagents such as Anti-C, Anti-c, Anti-E, Anti-e and Anti-K are used to determine the Rhesus-Kell phenotype of red blood cells in humans. These reagents are used to identify the presence of C, c, E, e and K antigens on the surface of the human red blood cells. These antigens are the third most potent at triggering an immune response in the blood, behind the ABO and Rh blood groups.

The importance of care and storage of samples and reagents

When using the reagents during testing, care has to be taken with handling blood samples, as there may be a risk of transmitting infection. The instructions for use provided by the manufacturer for using the reagents should be followed carefully and the reagents should only be used within their used by date. The reagents are designed for use at around room temperature and contamination with other substances needs to be avoided. For optimum use, and in order to keep these reagents in a good working condition they should be stored in a fridge. This means they should be kept below room temperature, between 2 and 8 °C.

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