Syphilis Assays

Torax Biosciences offers two types of agglutination test (RPR & TPHA) for the detection of Syphilis antibodies in human serum or plasma.

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Diagnosis of syphilis assays usually depends on the demonstration of antibodies in the blood. Two types of antibody are produced in response to infection, non-specific anti-lipid reagin antibody and specific anti-treponemal antibody. These appear soon after infection; the specific anti-treponemal antibodies may persist for many years, whereas the reagin antibodies may disappear after treatment.

Syphilis assays  can be used to run tests and can be grouped into two categories. Non-treponemal tests detect non-specific treponemal antibody and include RPRR and RPR tests, these are used primarily as screening tests. Treponemal tests detect specific treponemal antibody and include TPHA. These may also be used for screening and as confirmatory tests

RPR Rapin Plasma Reagin

RPR assay kits canbe used for the reliable detection of non-treponemal rapid plasma regain antibodies in human serum and plasma. Contains reagent, positive and negative controls, dispensing bottle and needle, slides and pipette stirrers.

Specially formulated to eliminate non-specific reactions and improve performance.

Results in 10 minutes.

RPR Carbon Antigen Reagent

The reagent consists of a suspension of cardiolipin / lecithin / cholesterol and carbon particles in order to improve the visual reading. Cardiolipid antigens react with the antibodies (reagin) present in the sample and form macroscopically visible black dumps.

Treponema Pallidum Haemagglutination Test Kits (TPHA)

Treponema pallidum haemagglutination test (TPHA) for the serodiagnosis of Syphilis.

The TPHA test kit is a sensitive passive haemagglutination test specifically designed for the detection of antibodies to Treponema pallidum.

  • Rapid: within little over 30 minutes of receiving the test sample or culture
  • Simple: ready-to-use reagents
  • Easy-to-read results
  • Excellent sensitivity: high quality specific antigens used in the test provide excellent sensitivity.

Tanned fowl erythrocytes are coated with specific antigen and suspended in a diluent 1,2,3. When diluted positive samples are mixed with the test suspension, antibody to the sensitising antigen causes agglutination of the cells. The cells form a characteristic pattern in the bottom of a microtitration plate well. In the absence of reacting antibody, the cells form a compact button in the well. Uncoated tanned fowl erythrocytes are used as the control cells.

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